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modafinil pills Although the particular mechanisms by which modafinil and R-enantiomer, armodafinil, decrease sleepiness are not totally understood, research suggests that these kind of agents promote wakefulness simply by acting indirectly on various components of the sleep / wake outlet. The most frequent uncomfortable side effects include changes in the heart rate, and dry jaws, headache, drowsiness, insomnia, nausea, vomiting, substantial anxiety. Some synergistic mixture of mechanisms among them direct deterrence of dopamine reuptake, indirect prevention of noradrenalin reuptake in the ventrolateral preoptic (VLPO) nucleus and orexin account activation has been caused by modafinil.